Salmonella: A bacteria with incredible diversity and application

July 8, 2018

Salmonella is a bacteria that can cause typhoid fever and diarrhea in humans and animals. For each year, 16 million cases of typhoid fever are reported and cause 600,000 deaths.[1] It also caused more than 15% of infection cases in the U.S. each year.[2] People spent several billion dollars annually to try to prevent Salmonella […]

How to Evaluate a Binary Classifier?

July 5, 2018

It is a common task to evaluate a binary classifier in the context of machine learning. In this blog, we will talk about what metrics to use for evaluating a binary classifier; the reason for the need of multiple metrics; how to plot a receiver operating characteristic (ROC) curve, how a random classifier works, and […]

Deep Learning Applied to Biology

June 16, 2018

I wanted to quickly take a moment to reflect on the work that our team has completed so far. We are in the midst of exciting state of the art research that fits at the intersection of deep learning and biological research. A few areas that we are currently involved in: • Optimal experimental design […]

Transfer learning – an Omics Prediction Solution?

June 15, 2018

Of late, training deep neural networks on tasks has become increasingly easier. Whether the task is image recognition, natural language processing, or gene expression prediction, if one has a large amount of data, one can train a model to map inputs to outputs with very high accuracy. The question subsequently becomes, how much data is […]

Research trends: Microbiome

June 8, 2018

Research in biomedical sciences has it’s trends as in many areas of science. I’ve become interested in microbiome research recently and might stay on it for number of years. As computational biologics, I wanted to quantitatively examine the growth in microbiome research. So I used ISI Web of Science. I performed two independent searches from […]

Beating the bad bugs using antimicrobial peptides

June 8, 2018

Emergence of antibiotic resistant bacteria at alarming rate is one of the major ongoing catastrophes. Most antibiotics are failing to control these bacteria, and now the emergence of “Super Bug” have created serious health-safety concerns. Researchers around the world have been trying to develop alternate methods to control the microbial infections. Antimicrobial peptides (AMPs) have […]

Triclosan: from hero to villain

June 7, 2018

For the fans of antimicrobial soaps, the determination by the Food and Drug Administration (FDA) to remove triclosan from antimicrobial soaps by the end of last year was an unpleasant surprise [1]. The rule was motivated by extensive research in the field suggesting harmful effects from triclosan exposure in animals and the development of antimicrobial […]

A network-based model for drug repurposing in Rheumatoid Arthritis

May 31, 2018

Jason Youn joins lab

April 21, 2018

Jason has a BS and a MS from Purdue in Electrical Engineering, where he graduated with highest distinction. He already has done some research in Deep Learning applications in computer vision and in our lab he will work on the ML/AI project that we are running for E. coli.

The Talking Democrats article: Cellular Activity Continues Hours After Death

March 1, 2018